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首页> Pediatric research> The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.

The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.

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作者： Jessica S,Wallisch ^[1] ; Keri,Janesko-Feldman ^[2] ; Henry,Alexander ^[3] ; Ruchira M,Jha ^[3] ; George W,Farr ^[3] ; Paul R,McGuirk ^[1] ; Anthony E,Kline ^[3] ; Travis C,Jackson ^[4] ; Marc F,Pelletier ^[4] ; Robert S B,Clark ^[3] ; Patrick M,Kochanek ^[5] ; Mioara D,Manole ^[1]

作者单位： Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA. ^[1] Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA. ^[2] Safar Center for Resuscitation Research, Pittsburgh, PA, USA. ^[3] Aeromics, Inc, Cleveland, OH, USA. ^[4] Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA. ^[5] Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. ^[6] Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA. mioara.manole@chp.edu. ^[7] Safar Center for Resuscitation Research, Pittsburgh, PA, USA. mioara.manole@chp.edu. ^[8] Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. mioara.manole@chp.edu. ^[9]

主题词动物(Animals);水通道蛋白质4(Aquaporin 4);窒息(Asphyxia);脑水肿(Brain Edema);CA1区, 海马(CA1 Region, Hippocampal);氯酚类(Chlorophenols);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);氟化合物(Fluorine Compounds);心脏停搏(Heart Arrest);人类(Humans);男(雄)性(Male);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);治疗结果(Treatment Outcome)

DOI 10.1038/s41390-018-0215-5

PMID 30367162

发布时间 2022-04-19

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Pediatric research

Pediatric research

2019年85卷4期

511-517页

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