Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions.

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作者： Marival,Bermejo ^[1] ; Paulo,Paixão ^[2] ; Bart,Hens ^[3] ; Yasuhiro,Tsume ^[1] ; Mark J,Koenigsknecht ^[4] ; Jason R,Baker ^[1] ; William L,Hasler ^[1] ; Robert,Lionberger ^[5] ; Jianghong,Fan ^[5] ; Joseph,Dickens ^[1] ; Kerby,Shedden ^[1] ; Bo,Wen ^[6] ; Jeffrey,Wysocki ^[1] ; Raimar,Löbenberg ^[1] ; Allen,Lee ^[1] ; Ann,Frances ^[1] ; Gregory E,Amidon ^[7] ; Alex,Yu ^[1] ; Niloufar,Salehi ^[1] ; Arjang,Talattof ^[1] ; Gail,Benninghoff ^[1] ; Duxin,Sun ^[1] ; Gislaine,Kuminek ^[1] ; Katie L,Cavanagh ^[1] ; Naír,Rodríguez-Hornedo ; Gordon L,Amidon

作者单位： Department of Pharmaceutical Sciences, College of Pharmacy , University of Michigan , 428 Church Street , Ann Arbor , Michigan 48109-1065 , United States. ^[1] Department of Engineering, Pharmacy Section , Miguel Hernandez University , San Juan de Alicante, 03550 Alicante , Spain. ^[2] Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy , Universidade de Lisboa , Avenida Professor Gama Pinto , 1649-003 Lisboa , Portugal. ^[3] Department of Pharmaceutical and Pharmacological Sciences , KU Leuven , Herestraat 49 , 3000 Leuven , Belgium. ^[4] Office of Generic Drugs, Center for Drug Evaluation and Research , U.S. Food and Drug Administration , Silver Spring , Maryland 20993 , United States. ^[5] Faculty of Pharmacy & Pharmaceutical Sciences , University of Alberta , Edmonton , Alberta , Canada T6G 2H7. ^[6] Center for the Study of Complex Systems and Department of Chemical Engineering , University of Michigan , Ann Arbor , Michigan 48109-2136 , United States. ^[7]

关键词 aspiration/motility study bioavailability bioequivalence ibuprofen immediate release in vivo dissolution local drug concentration in the GI tract manometry motility oral absorption