Isolation and Characterization of Poecistasin, an Anti-Thrombotic Antistasin-Type Serine Protease Inhibitor from Leech <i>Poecilobdella manillensis</i>.

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第一作者： Xiaopeng,Tang

第一单位： Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. tangxiaopeng@mail.kiz.ac.cn.

作者： Xiaopeng,Tang ^[1] ; Mengrou,Chen ^[2] ; Zilei,Duan ^[3] ; James,Mwangi ^[4] ; Pengpeng,Li ^[5] ; Ren,Lai ^[6]

作者单位： Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. tangxiaopeng@mail.kiz.ac.cn. ^[1] Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, Yunnan, China. tangxiaopeng@mail.kiz.ac.cn. ^[2] College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China. chenmengrou@outlook.com. ^[3] Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. duanzilei@mail.kiz.ac.cn. ^[4] Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. mwangij1124@yahoo.com. ^[5] Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, Yunnan, China. mwangij1124@yahoo.com. ^[6] College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China. pengpengli59@gmail.com. ^[7] Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. rlai@mail.kiz.ac.cn. ^[8] College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China. rlai@mail.kiz.ac.cn. ^[9]

关键词 Antistasin-type inhibitor Poecilobdella manillensis coagulation ischemic stroke poecistasin thrombus formation