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Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11.

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第一作者： Anastasios,Spiliotopoulos

第一单位： From the Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD.;the School of Veterinary Medicine and Science, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire LE12 5RD.

作者： Anastasios,Spiliotopoulos ^[1] ; Lia,Blokpoel Ferreras ^[2] ; Ruth M,Densham ^[3] ; Simon G,Caulton ^[2] ; Ben C,Maddison ^[4] ; Joanna R,Morris ^[3] ; James E,Dixon ^[2] ; Kevin C,Gough ^[5] ; Ingrid,Dreveny ^[6]

作者单位： From the Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD.;the School of Veterinary Medicine and Science, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire LE12 5RD. ^[1] From the Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD. ^[2] the Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, Medical and Dental Schools, University of Birmingham, Birmingham B15 2TT, and. ^[3] ADAS, School of Veterinary Medicine and Science, Bonington Campus, College Road, Sutton Bonington, Leicestershire LE12 5RD, United Kingdom. ^[4] the School of Veterinary Medicine and Science, Sutton Bonington Campus, College Road, Sutton Bonington, Leicestershire LE12 5RD, kevin.gough@nottingham.ac.uk. ^[5] From the Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, ingrid.dreveny@nottingham.ac.uk. ^[6]

关键词 DNA damage response USP11 cell-penetrating peptide (CPP)crystal structure deubiquitylation (deubiquitination)molecular recognition peptide interaction peptides phage display protease ubiquitin ubiquitin-dependent protease