Scale-Up Procedure for Primary Drying Process in Lyophilizer by Using the Vial Heat Transfer and the Drying Resistance.

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第一作者： Hidenori,Kawasaki

第一单位： Graduate School of Environmental and Life Science, Okayama University.;Formulation R&D Center, CMC R&D Division, Shionogi & Co., Ltd.

作者： Hidenori,Kawasaki ^[1] ; Toshinori,Shimanouchi ^[2] ; Masaharu,Yamamoto ^[3] ; Kanako,Takahashi ^[4] ; Yukitaka,Kimura ^[2]

作者单位： Graduate School of Environmental and Life Science, Okayama University.;Formulation R&D Center, CMC R&D Division, Shionogi & Co., Ltd. ^[1] Graduate School of Environmental and Life Science, Okayama University. ^[2] Production Planning Department, Manufacturing Division, Shionogi & Co., Ltd. ^[3] Formulation R&D Center, CMC R&D Division, Shionogi & Co., Ltd. ^[4]

关键词 lyophilization primary drying sublimation vial heat transfer coefficient water vapor transfer resistance

主题词能量传递(Energy Transfer);冷冻干燥法(Freeze Drying);热温度(Hot Temperature);挥发作用(Volatilization);水(Water)

DOI 10.1248/cpb.c18-00516

PMID 30381657

发布时间 2018-11-08

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