Epigenetics in amyotrophic lateral sclerosis: a role for histone post-translational modifications in neurodegenerative disease.
第一作者:
Seth A,Bennett
第一单位:
Department of Chemistry, Brooklyn College, Brooklyn, NewYork; Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, New York.
作者:
关键词
3′-UTR3′-untranslated regionALSAMPAC9orf72DREFTDFUSHATHCPHDACNFLPRMTPTMRISCRNA-induced silencing complexSIRTSMNSOD1SUV39HTAR DNA-binding protein 43TDP-43amyotrophic lateral sclerosischromosome 9 open reading frame 72dipeptide repeat expansionfrontotemporal dementiafused In sarcomahigh-CpG-density promoterhistone acetyltransferasehistone deacetylaselow-molecular weight neurofilamentmiRNAmicroRNApost-translational modificationprotein arginine N-methyltransferasesirtuinsuperoxide dismutase 1suppressor of variegation 3-9 homologue 1survival of motor neuronα-amino-3-hydroxy-5-methyl-4-isoxazole propionic Acid
主题词
乙酰化作用(Acetylation);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);动物(Animals);染色质组装和分解(Chromatin Assembly and Disassembly);DNA甲基化(DNA Methylation);后成说, 遗传(Epigenesis, Genetic);组蛋白类(Histones);人类(Humans);微RNAs(MicroRNAs);蛋白质加工, 转译后(Protein Processing, Post-Translational)
DOI
10.1016/j.trsl.2018.10.002
PMID
30391475
发布时间
2020-03-09
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Translational research
19-30页
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