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The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection.

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第一作者： Hideki,Hara

第一单位： Department of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: hhara@med.umich.edu.

作者： Hideki,Hara ^[1] ; Sergey S,Seregin ^[2] ; Dahai,Yang ^[3] ; Koichi,Fukase ^[4] ; Mathias,Chamaillard ^[5] ; Emad S,Alnemri ^[6] ; Naohiro,Inohara ^[3] ; Grace Y,Chen ^[2] ; Gabriel,Núñez ^[7]

作者单位： Department of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: hhara@med.umich.edu. ^[1] Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[2] Department of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ^[3] Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan. ^[4] CIIL-Centre d'Infection et d'Immunité de Lille, Université de Lille, CNRS, Inserm, CHRU Lille, Institut Pasteur de Lille, U1019-UMR 8204, F-59000, Lille, France. ^[5] Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. ^[6] Department of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: gabriel.nunez@umich.edu. ^[7]

关键词 IL-18 Listeria monocytogenes NLRP6 caspase-1 caspase-11 gram-positive bacteria inflammasome lipoteichoic acid