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首页> PLoS pathogens> HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.

HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.

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作者： Celia C,LaBranche ^[1] ; Andrew T,McGuire ^[2] ; Matthew D,Gray ^[2] ; Shay,Behrens ^[1] ; Peter D,Kwong ^[3] ; Xuejun,Chen ^[3] ; Tongqing,Zhou ^[4] ; Quentin J,Sattentau ^[5] ; James,Peacock ^[1] ; Amanda,Eaton ^[1] ; Kelli,Greene ^[1] ; Hongmei,Gao ^[1] ; Haili,Tang ^[1] ; Lautaro G,Perez ^[1] ; Xuejun,Chen ^[3] ; Kevin O,Saunders ^[3] ; Peter D,Kwong ^[5] ; John R,Mascola ^[2] ; Barton F,Haynes ^[6] ; Leonidas,Stamatatos ^[1] ; David C,Montefiori

作者单位： Department of Surgery, Duke University Medical Center, Durham, NC, United States of America. ^[1] Fred Hutchinson Cancer Research Center, Department of Global Health, Seattle, WA, United States of America. ^[2] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America. ^[3] The Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, United Kingdom. ^[4] Duke University School of Medicine, Departments of Medicine and Immunology, Duke Human Vaccine Institute, Durham, NC, United States of America. ^[5] University of Washington, Department of Global Health, Seattle, Washington, United States of America. ^[6]

主题词抗体, 单克隆(Antibodies, Monoclonal);抗体, 中和(Antibodies, Neutralizing);B-淋巴细胞(B-Lymphocytes);结合部位(Binding Sites);表位(Epitopes);糖基化(Glycosylation);HIV抗体(HIV Antibodies);HIV包膜蛋白质gp120(HIV Envelope Protein gp120);HIV感染(HIV Infections);HIV血清阳性(HIV Seropositivity);HIV-1(HIV-1);人类(Humans);多糖类(Polysaccharides);env基因产物, 人免疫缺陷病毒(env Gene Products, Human Immunodeficiency Virus)

DOI 10.1371/journal.ppat.1007431

PMID 30395637

发布时间 2022-01-29

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PLoS pathogens

PLoS pathogens

2018年14卷11期

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