A Novel Mecp2<sup>Y120D</sup> Knock-in Model Displays Similar Behavioral Traits But Distinct Molecular Features Compared to the Mecp2-Null Mouse Implying Precision Medicine for the Treatment of Rett Syndrome.

导出原文传递

翻译打印收藏纠错

作者： Anna,Gandaglia ^[1] ; Elena,Brivio ^[1] ; Sara,Carli ^[2] ; Michela,Palmieri ^[1] ; Francesco,Bedogni ^[1] ; Gilda,Stefanelli ^[1] ; Anna,Bergo ^[1] ; Barbara,Leva ^[3] ; Chiara,Cattaneo ^[4] ; Lara,Pizzamiglio ^[4] ; Marco,Cicerone ^[1] ; Veronica,Bianchi ^[5] ; Charlotte,Kilstrup-Nielsen ^[6] ; Ilda,D'Annessa ^[1] ; Daniele,Di Marino ^[1] ; Patrizia,D'Adamo ^[4] ; Flavia,Antonucci ^[7] ; Angelisa,Frasca ^[8] ; Nicoletta,Landsberger ^[1]

作者单位： Neuroscience Division, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy. ^[1] Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, International Max Planck Research School for Translational Psychiatry, 80804, Munich, Germany. ^[2] Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, L5L 1C6, Canada. ^[3] Department of Biotechnology and Life Sciences, University of Insubria, 21052, Busto Arsizio, VA, Italy. ^[4] Department of Molecular Oncology and Immunology, the Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands. ^[5] Department of Medical Biotechnology and Translational Medicine, University of Milan, 20100, Milan, Italy. ^[6] Istituto di Chimica del Riconoscimento Molecolare, CNR (ICRM-CNR), 20131, Milan, Italy. ^[7] Department of Informatics, Institute of Computational Science, Università della Svizzera Italiana, 6900, Lugano, Switzerland. ^[8] Neuroscience Division, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy. nicoletta.landsberger@unimi.it. ^[9] Department of Medical Biotechnology and Translational Medicine, University of Milan, 20100, Milan, Italy. nicoletta.landsberger@unimi.it. ^[10]

关键词 Chromatin accessibility Chromatin binding MeCP2 Mouse models Rett syndrome