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PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.

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作者单位: Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA. [1] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.;Deparment of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland. [2] Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.;Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. [3] Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.;Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.;Department of Pediatric Oncology, University Hospital Muenster, Muenster, Germany. [4] Center for Medical Genetics, Ghent University, Ghent, Belgium.;Cancer Research Institute Ghent (CRIG), Ghent, Belgium. [5] Center for Medical Genetics, Ghent University, Ghent, Belgium. [6] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. [7] Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA. [8] Department of Biostatistics, University of Florida, Gainesville, FL. [9] Department of Pediatrics, University of California San Francisco, San Francisco, CA. [10] Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA. [11] Division of Pediatric Hematology/Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX. [12] Cancer and Blood Disorders Department, Children's Minnesota, Minneapolis, MN. [13] Department of Pediatrics, Carilion Children's, Roanoke, VA. [14] Department of Laboratory Medicine, University of Washington, Seattle, WA. [15] Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.;Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.;Howard Hughes Medical Institute, Boston, MA. [16] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. [17] Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA alejandro.gutierrez@childrens.harvard.edu.;Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. [18]
DOI 10.1084/jem.20180570
PMID 30404791
发布时间 2024-09-22
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