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首页> Bioorganic & medicinal chemistry letters> Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors.

Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors.

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作者： Qiangang,Zheng ^[1] ; Ziqi,Chen ^[2] ; Huixin,Wan ^[1] ; Shuai,Tang ^[3] ; Yan,Ye ^[4] ; Yuan,Xu ^[4] ; Lei,Jiang ^[1] ; Jian,Ding ^[2] ; Meiyu,Geng ^[2] ; Min,Huang ^[2] ; Ying,Huang ^[5]

作者单位： Shanghai Haihe Pharmaceutical, Co., Ltd. 421 Newton Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China. ^[1] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. ^[2] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China. ^[3] Shanghai Haihe Pharmaceutical, Co., Ltd. 421 Newton Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China. ^[4] Shanghai Haihe Pharmaceutical, Co., Ltd. 421 Newton Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China. Electronic address: yingrhuang@gmail.com. ^[5]

关键词 IDH1 inhibitor Imidazole cyclopropyl amine Structure-based rational design

主题词胺类(Amines);动物(Animals);细胞系(Cell Line);药物设计(Drug Design);药物发现(Drug Discovery);酶抑制剂(Enzyme Inhibitors);人类(Humans);咪唑类(Imidazoles);异柠檬酸脱氢酶(Isocitrate Dehydrogenase);小鼠(Mice);微粒体, 肝(Microsomes, Liver);突变(Mutation);大鼠(Rats);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bmcl.2018.07.002

PMID 30413349

发布时间 2019-07-22

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Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

2018年28卷23-24期

3808-3812页

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Bioorganic & medicinal chemistry letters

2018年28卷23-24期

3808-3812页

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