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首页> Life sciences> Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke.

Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke.

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作者： Kanta,Pravalika ^[1] ; Deepaneeta,Sarmah ^[1] ; Harpreet,Kaur ^[1] ; Kanchan,Vats ^[1] ; Jackson,Saraf ^[1] ; Madhuri,Wanve ^[1] ; Kiran,Kalia ^[1] ; Anupom,Borah ^[2] ; Dileep R,Yavagal ^[3] ; Kunjan R,Dave ^[4] ; Pallab,Bhattacharya ^[5]

作者单位： Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India. ^[1] Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, India. ^[2] Department of Neurology and Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA. ^[3] Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA. ^[4] Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India. Electronic address: pallab.bhattacharya@niperahm.ac.in. ^[5]

关键词 Ischemic stroke Myeloperoxidase Neuroprotection Trigonelline

主题词生物碱类(Alkaloids);苯胺化合物(Aniline Compounds);动物(Animals);抗氧化剂(Antioxidants);印迹法, 蛋白质(Blotting, Western);脑缺血(Brain Ischemia);大脑梗死(Cerebral Infarction);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);谷胱甘肽(Glutathione);男(雄)性(Male);神经保护药(Neuroprotective Agents);过氧化物酶(Peroxidase);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);卒中(Stroke)

DOI 10.1016/j.lfs.2018.11.014

PMID 30414429

发布时间 2019-01-07

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