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首页> International immunopharmacology> A novel all-trans retinoic acid derivative inhibits proliferation and induces apoptosis of myelodysplastic syndromes cell line SKM-1 cells via up-regulating p53.

A novel all-trans retinoic acid derivative inhibits proliferation and induces apoptosis of myelodysplastic syndromes cell line SKM-1 cells via up-regulating p53.

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作者： Yan,Du ^[1] ; Lan-Lan,Li ^[1] ; Hao,Chen ^[1] ; Cong,Wang ^[1] ; Xue-Wen,Qian ^[1] ; Yu-Bin,Feng ^[1] ; Lei,Zhang ^[1] ; Fei-Hu,Chen ^[2]

作者单位： School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei 230032, China; Institute for Liver Disease of Anhui Medical University, Anhui Medical University, Hefei 230032, China. ^[1] School of Pharmacy, Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei 230032, China; Institute for Liver Disease of Anhui Medical University, Anhui Medical University, Hefei 230032, China. Electronic address: cfhchina@sohu.com. ^[2]

关键词 4-Amino-2-trifluoromethyl-phenyl retinate (ATPR)Apoptosis Myelodysplastic syndromes (MDS)p53

主题词细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);基因表达调控(Gene Expression Regulation);人类(Humans);膜蛋白质类(Membrane Proteins);骨髓增生异常综合征(Myelodysplastic Syndromes);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);RNA, 小分子干扰(RNA, Small Interfering);维生素A酸类(Retinoids);信号传导(Signal Transduction);维甲酸(Tretinoin);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);bcl-2相关X蛋白质(bcl-2-Associated X Protein)

DOI 10.1016/j.intimp.2018.10.041

PMID 30415163

发布时间 2019-04-08

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International immunopharmacology

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