Hydrophilic bile acids prevent liver damage caused by lack of biliary phospholipid in <i>Mdr2<sup>-/-</sup></i> mice.

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作者： Renxue,Wang ^[1] ; Jonathan A,Sheps ^[1] ; Lin,Liu ^[1] ; Jun,Han ^[2] ; Patrick S K,Chen ^[3] ; Jason,Lamontagne ^[3] ; Peter D,Wilson ^[3] ; Ian,Welch ^[4] ; Christoph H,Borchers ^[5] ; Victor,Ling ^[2]

作者单位： BC Cancer Research Centre, Vancouver, British Columbia, Canada. ^[1] University of Victoria-Genome BC Proteomics Centre University of Victoria, Victoria, British Columbia, Canada. ^[2] Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada. ^[3] Department of Pathology University of British Columbia, Vancouver, British Columbia, Canada. ^[4] Centre for Comparative Medicine, University of British Columbia, Vancouver, British Columbia, Canada. ^[5] Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada. ^[6] Proteomics Centre, Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. ^[7] BC Cancer Research Centre, Vancouver, British Columbia, Canada vling@bccrc.ca. ^[8]

关键词 bile acids and salts/biosynthesis cancer gene expression hepatic cellular carcinoma hydrophobicity inflammation liver fibrosis progressive familial intrahepatic cholestasis tetrahydroxylated bile acids