Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.-论文-万方医学网

作者： Zhi-Chao,Hu ^[1] ; Lan-Fang,Gong ^[2] ; Xiao-Bin,Li ^[3] ; Xin,Fu ^[4] ; Jiang-Wei,Xuan ^[1] ; Zhen-Hua,Feng ^[2] ; Wen-Fei,Ni ^[3]

作者单位： Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. ^[1] Department of The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. ^[2] Department of Bone Research Institute, The Key Orthopaedic Laboratory of Zhejiang Province, Wenzhou, Zhejiang, China. ^[3] Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, The First Medical School of the Wenzhou Medical University, Wenzhou, Zhejiang, China. ^[4] Department of Orthopaedics, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China. ^[5]

主题词动物(Animals);细胞, 培养的(Cells, Cultured);环氧化酶2(Cyclooxygenase 2);地诺前列酮(Dinoprostone);减量调节(Down-Regulation);细胞外基质(Extracellular Matrix);没食子酸(Gallic Acid);人类(Humans);白细胞介素1β(Interleukin-1beta);白细胞介素6(Interleukin-6);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);NF-κB(NF-kappa B);一氧化氮(Nitric Oxide);一氧化氮合酶Ⅱ型(Nitric Oxide Synthase Type II);骨关节炎(Osteoarthritis);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);预防和防护用药(Protective Agents);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);信号传导(Signal Transduction)

DOI 10.1002/jcp.27437

PMID 30417459

发布时间 2020-03-30

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Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.

Journal of cellular physiology

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Journal of cellular physiology

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Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.

Journal of cellular physiology

相似文献

Journal of cellular physiology

相关期刊

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