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首页> Nature medicine> Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.

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作者： Daniel A,Pollyea ^[1] ; Brett M,Stevens ^[1] ; Courtney L,Jones ^[1] ; Amanda,Winters ^[2] ; Shanshan,Pei ^[1] ; Mohammad,Minhajuddin ^[1] ; Angelo,D'Alessandro ^[3] ; Rachel,Culp-Hill ^[3] ; Kent A,Riemondy ^[4] ; Austin E,Gillen ^[4] ; Jay R,Hesselberth ^[3] ; Diana,Abbott ^[4] ; Derek,Schatz ^[5] ; Jonathan A,Gutman ^[1] ; Enkhtsetseg,Purev ^[1] ; Clayton,Smith ^[1] ; Craig T,Jordan ^[1]

作者单位： Division of Hematology, University of Colorado School of Medicine, Aurora, CO, USA. ^[1] Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. ^[2] Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA. ^[3] RNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, CO, USA. ^[4] Department of Biostatistics and Informatics, University of Colorado School of Medicine, Aurora, CO, USA. ^[5] Division of Hematology, University of Colorado School of Medicine, Aurora, CO, USA. Craig.jordan@ucdenver.edu. ^[6]

主题词老年人(Aged);老年人, 80以上(Aged, 80 and over);细胞凋亡(Apoptosis);阿扎胞苷(Azacitidine);电子传递复合物Ⅱ(Electron Transport Complex II);能量代谢(Energy Metabolism);女(雌)性(Female);人类(Humans);酮戊二酸类(Ketoglutaric Acids);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);男(雄)性(Male);肿瘤干细胞(Neoplastic Stem Cells);氧化磷酸化(Oxidative Phosphorylation);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);琥珀酸脱氢酶(Succinate Dehydrogenase);磺胺类(Sulfonamides);三羧酸类(Tricarboxylic Acids)

DOI 10.1038/s41591-018-0233-1

PMID 30420752

发布时间 2021-05-14

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Nature medicine

Nature medicine

2018年24卷12期

1859-1866页

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