SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.

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作者： Simon,Leiris ^[1] ; Alicia,Coelho ^[1] ; Jérôme,Castandet ^[1] ; Maëlle,Bayet ^[1] ; Clarisse,Lozano ^[1] ; Juliette,Bougnon ^[1] ; Justine,Bousquet ^[1] ; Martin,Everett ^[1] ; Marc,Lemonnier ^[1] ; Nicolas,Sprynski ^[1] ; Magdalena,Zalacain ^[1] ; Thomas David,Pallin ^[2] ; Michael C,Cramp ^[3] ; Neil,Jennings ^[3] ; Gilles,Raphy ^[3] ; Mark W,Jones ^[3] ; Ramesh,Pattipati ^[3] ; Battu,Shankar ^[4] ; Relangi,Sivasubrahmanyam ^[4] ; Ashok K,Soodhagani ^[4] ; Ramakrishna R,Juventhala ^[4] ; Narender,Pottabathini ^[4] ; Srinivasu,Pothukanuri ^[4] ; Manuela,Benvenuti ^[4] ; Cecilia,Pozzi ^[5] ; Stefano,Mangani ^[5] ; Filomena,De Luca ^[5] ; Giulia,Cerboni ^[6] ; Jean-Denis,Docquier ^[6] ; David T,Davies ^[6]

作者单位： Antabio SAS , 436 rue Pierre et Marie Curie , 31670 Labège , France. ^[1] Zala Drug Discovery Consulting LLC , West Chester , Pennsylvania 19380 , United States. ^[2] Charles River Laboratories , 8-9 The Spire Green Centre , Harlow CM19 5TR , United Kingdom. ^[3] GVK Biosciences Private Limited , Plot No. 28 A , IDA Nacharam , Hyderabad 500076 , India. ^[4] Department of Biotechnology, Chemistry and Pharmacy , University of Siena , 2 Via Aldo Moro , Siena , 53100 Italy. ^[5] Department of Medical Biotechnology , University of Siena , 16 Viale Bracci , Siena , 53100 Italy. ^[6]

关键词 NDM-1 VIM-2 antibiotic resistance efficacy meropenem metallo-β-lactamase inhibitor

主题词抗菌药(Anti-Bacterial Agents);卡巴配能类(Carbapenems);结晶学, X线(Crystallography, X-Ray);抗药性, 多种, 细菌(Drug Resistance, Multiple, Bacterial);肠杆菌科感染(Enterobacteriaceae Infections);半数抑制浓度(Inhibitory Concentration 50);微生物敏感性试验(Microbial Sensitivity Tests);吡啶羧酸类(Picolinic Acids);蛋白质结合(Protein Binding);构效关系(Structure-Activity Relationship);β-内酰胺酶类(beta-Lactamases)

DOI 10.1021/acsinfecdis.8b00246

PMID 30427656

发布时间 2021-01-09

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ACS infectious diseases

2019年5卷1期

131-140页

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SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.

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SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.

ACS infectious diseases

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ACS infectious diseases

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