In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model.

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作者： Ami,Patel ^[1] ; Daniel H,Park ^[1] ; Carl W,Davis ^[2] ; Trevor R F,Smith ^[3] ; Anders,Leung ^[4] ; Kevin,Tierney ^[4] ; Aubrey,Bryan ^[5] ; Edgar,Davidson ^[5] ; Xiaoying,Yu ^[6] ; Trina,Racine ^[7] ; Charles,Reed ^[3] ; Marguerite E,Gorman ^[8] ; Megan C,Wise ^[3] ; Sarah T C,Elliott ^[1] ; Rianne,Esquivel ^[1] ; Jian,Yan ^[3] ; Jing,Chen ^[3] ; Kar,Muthumani ^[1] ; Benjamin J,Doranz ^[5] ; Erica Ollmann,Saphire ^[6] ; James E,Crowe ^[9] ; Kate E,Broderick ^[3] ; Gary P,Kobinger ^[10] ; Shihua,He ^[4] ; Xiangguo,Qiu ^[7] ; Darwyn,Kobasa ^[7] ; Laurent,Humeau ^[3] ; Niranjan Y,Sardesai ^[3] ; Rafi,Ahmed ^[2] ; David B,Weiner ^[11]

作者单位： The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, USA. ^[1] Emory Vaccine Center, Emory University, Atlanta, GA 30317, USA. ^[2] Inovio Pharmaceuticals, Plymouth Meeting, PA 19462, USA. ^[3] Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada. ^[4] Integral Molecular, Philadelphia, PA 19104, USA. ^[5] The Scripps Research Institute, La Jolla, CA 92037, USA. ^[6] Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada; University of Manitoba, Winnipeg, MB R3T 2N2, Canada. ^[7] The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, USA; Boston College, Newton, MA 02467, USA. ^[8] Vanderbilt University, Nashville, TN 37235, USA. ^[9] Université Laval, Quebec City, QC G1V 0A6, Canada. ^[10] The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, USA. Electronic address: dweiner@wistar.org. ^[11]

关键词 DMAb DNA DNA-encoded monoclonal antibody EBOV Ebola virus disease Zaire ebolavirus electroporation glycoprotein immunoprophylaxis monoclonal antibody