TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma.

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作者： Lisa J,Hill ^[1] ; Ben,Mead ^[2] ; Chloe N,Thomas ^[3] ; Simon,Foale ^[3] ; Elena,Feinstein ^[3] ; Martin,Berry ^[4] ; Richard J,Blanch ^[3] ; Zubair,Ahmed ^[3] ; Ann,Logan ^[5]

作者单位： Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom. ^[1] Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD. ^[2] Neuroscience and Ophthalmology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom. ^[3] Research Division, Quark Pharmaceuticals, Ness Ziona, Israel. ^[4] Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Birmingham, UK. ^[5]

主题词动物(Animals);疾病模型, 动物(Disease Models, Animal);纤维化(Fibrosis);青光眼, 开角型(Glaucoma, Open-Angle);眼内压(Intraocular Pressure);RNA干扰(RNA Interference);RNA, 小分子干扰(RNA, Small Interfering);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);视网膜神经节细胞(Retinal Ganglion Cells);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);眼压测量法(Tonometry, Ocular);小梁网(Trabecular Meshwork);转化生长因子β1(Transforming Growth Factor beta1);ρA GTP结合蛋白质(rhoA GTP-Binding Protein)

PMID 30429640

发布时间 2024-04-26

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Molecular vision

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TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma.

Molecular vision

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Molecular vision

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TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma.

Molecular vision

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Molecular vision

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