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Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.

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作者单位: Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden. [1] Department of Biotechnology and Nanomedicine, SINTEF Industry, N-7465 Trondheim, Norway. [2] Department of Microbiology and Immunology, Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. [3] Department of Biochemistry and Biophysics, Stockholm University, S-106 91 Stockholm, Sweden. [4] Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. [5] The Liaison Committee for Education, Research, and Innovation in Central Norway, Trondheim, Norway. [6] Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-17177 Stockholm, Sweden. [7] SciLifeLab, SE-17121 Solna, Sweden. [8] Science for Life Laboratory Drug Discovery and Development Platform, ADME of Therapeutics Facility, Department of Pharmacy, Uppsala University, Uppsala, Sweden. [9] Uppsala Drug Optimisation and Pharmaceutical Profiling Platform (UDOPP), Department of Pharmacy, Uppsala University, Uppsala, Sweden. [10] Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21 Stockholm, Sweden. [11] Department of Pharmacological and Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow, Russia. [12] Department of Experimental Medical Science, Lund University, Lund, Sweden. [13] Department of Microbiology and Immunology, Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA. sboldogh@utmb.edu t.helleday@sheffield.ac.uk. [14] Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden. sboldogh@utmb.edu t.helleday@sheffield.ac.uk. [15] Sheffield Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK. [16]
DOI 10.1126/science.aar8048
PMID 30442810
发布时间 2021-02-19
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