Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture.-论文-万方医学网

第一作者： Silvia,Villahoz

第一单位： Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain.

作者： Silvia,Villahoz ^[1] ; Paula Sofía,Yunes-Leites ^[2] ; Nerea,Méndez-Barbero ^[1] ; Katia,Urso ^[2] ; Elena,Bonzon-Kulichenko ^[1] ; Sagrario,Ortega ^[3] ; J Francisco,Nistal ^[1] ; Jesus,Vazquez ^[4] ; Stefan,Offermanns ^[2] ; Juan Miguel,Redondo ^[5] ; Miguel R,Campanero ^[6]

作者单位： Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain. ^[1] Centro de Investigaciones Biomédicas en RED en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. ^[2] Vascular Research Lab., IIS-Fundación Jiménez Díaz, Autonomous University of Madrid, Madrid, 28040, Spain. ^[3] ITF Research Pharma, Alcobendas, Madrid, 28108, Spain. ^[4] Cardiovascular Proteomics Laboratory, CNIC, Madrid, 28029, Spain. ^[5] Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain. ^[6] Cardiovascular Surgery, Hospital Universitario Marqués de Valdecilla, IDIVAL, Facultad de Medicina, Universidad de Cantabria, Santander, 39008, Spain. ^[7] Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, 61231, Germany. ^[8] Gene regulation in cardiovascular remodeling and inflammation group, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain. jmredondo@cnic.es. ^[9] Centro de Investigaciones Biomédicas en RED en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. jmredondo@cnic.es. ^[10] Centro de Investigaciones Biomédicas en RED en Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. mcampanero@iib.uam.es. ^[11] Department of Cancer Biology, Instituto de Investigaciones Biomedicas Alberto Sols, CSIC-UAM, Madrid, 28029, Spain. mcampanero@iib.uam.es. ^[12]

主题词动物(Animals);抗高血压药(Antihypertensive Agents);主动脉(Aorta);主动脉破裂(Aortic Rupture);钙结合蛋白质类(Calcium-Binding Proteins);疾病模型, 动物(Disease Models, Animal);内皮细胞(Endothelial Cells);基因缺失(Gene Deletion);基因表达调控(Gene Expression Regulation);疾病遗传易感性(Genetic Predisposition to Disease);血肿(Hematoma);人类(Humans);高血压(Hypertension);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);肌蛋白质类(Muscle Proteins);肌细胞, 平滑肌(Myocytes, Smooth Muscle);蛋白质亚型(Protein Isoforms);蛋白激酶抑制剂(Protein Kinase Inhibitors);rho相关激酶类(rho-Associated Kinases)

DOI 10.1038/s41467-018-07071-7

PMID 30442942

发布时间 2022-12-07

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Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture.

Nature communications

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Nature communications

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Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture.

Nature communications

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Nature communications

相关期刊

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