Loss of the Chr16p11.2 ASD candidate gene <i>QPRT</i> leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model.

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作者： Denise,Haslinger ^[1] ; Regina,Waltes ^[1] ; Afsheen,Yousaf ^[1] ; Silvia,Lindlar ^[1] ; Ines,Schneider ^[2] ; Chai K,Lim ^[3] ; Meng-Miao,Tsai ^[4] ; Boyan K,Garvalov ^[4] ; Amparo,Acker-Palmer ^[5] ; Nicolas,Krezdorn ^[6] ; Björn,Rotter ^[7] ; Till,Acker ^[7] ; Gilles J,Guillemin ^[4] ; Simone,Fulda ^[3] ; Christine M,Freitag ^[2] ; Andreas G,Chiocchetti ^[1]

作者单位： 1Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt, JW Goethe University Frankfurt, Frankfurt am Main, Germany. ^[1] Institute of Experimental Cancer Research in Pediatrics, Frankfurt am Main, Germany. ^[2] 3Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales Australia. ^[3] 4Neuropathology, University of Giessen, Giessen, Germany. ^[4] 5Department of Microvascular Biology and Pathobiology, European Center for Angioscience (ECAS), Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. ^[5] 6Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), JW Goethe University of Frankfurt, Frankfurt am Main, Germany. ^[6] 7GenXPro GmbH, Frankfurt am Main, Germany. ^[7]

关键词 16p11.2 Autism CRISPR/Cas9 Kynurenine Quinolinate phosphoribosyltransferase Quinolinic acid Sholl analysis