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Hunting for the high-affinity state of G-protein-coupled receptors with agonist tracers: Theoretical and practical considerations for positron emission tomography imaging.

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第一作者： Vladimir,Shalgunov

第一单位： Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

作者： Vladimir,Shalgunov ^[1] ; Aren,van Waarde ^[1] ; Jan,Booij ^[2] ; Martin C,Michel ^[3] ; Rudi A J O,Dierckx ^[4] ; Philip H,Elsinga ^[1]

作者单位： Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. ^[1] Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. ^[2] Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany. ^[3] Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.;Department of Nuclear Medicine, Ghent University, University Hospital, Ghent, Belgium. ^[4]

关键词 G-protein-coupled receptors agonist high-affinity state experimental design human brain neurotransmitters positron emission tomography