Synthesis, biological evaluation and molecular dynamic simulations of novel Benzofuran-tetrazole derivatives as potential agents against Alzheimer's disease.

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作者： Pragati,Kushwaha ^[1] ; Soobiya,Fatima ^[2] ; Akanksha,Upadhyay ^[1] ; Sampa,Gupta ^[1] ; Sudha,Bhagwati ^[3] ; Tanvi,Baghel ^[4] ; M I,Siddiqi ^[3] ; Aamir,Nazir ^[2] ; Koneni V,Sashidhara ^[5]

作者单位： Medicinal and Process Chemistry Division, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. ^[1] Division of Toxicology and Experimental Medicine, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. ^[2] Molecular and Structural Biology Division, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. ^[3] Division of Toxicology and Experimental Medicine, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. ^[4] Medicinal and Process Chemistry Division, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. Electronic address: kv_sashidhara@cdri.res.in. ^[5]

关键词 Amyloid-beta aggregation Benzofuran-tetrazole derivatives Molecular hybridization TcAChE–E2020 complex