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首页> Proceedings of the National Academy of Sciences of the United States of America> Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins.

Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins.

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作者： F Donelson,Smith ^[1] ; Mitchell H,Omar ^[1] ; Patrick J,Nygren ^[1] ; Joseph,Soughayer ^[1] ; Naoto,Hoshi ^[2] ; Ho-Tak,Lau ^[1] ; Calvin G,Snyder ^[1] ; Tess C,Branon ^[3] ; Debapriya,Ghosh ^[4] ; Lorene K,Langeberg ^[5] ; Alice Y,Ting ^[6] ; Luis F,Santana ^[1] ; Shao-En,Ong ^[3] ; Manuel F,Navedo ^[4] ; John D,Scott ^[5]

作者单位： Department of Pharmacology, University of Washington, Seattle, WA 98195. ^[1] Department of Pharmacology, University of California, Irvine, CA 92697. ^[2] Department of Genetics, Stanford University, Stanford, CA 94305. ^[3] Department of Biology, Stanford University, Stanford, CA 94305. ^[4] Department of Chemistry, Stanford University, Stanford, CA 94305. ^[5] Department of Pharmacology, University of California, Davis, CA 95616. ^[6] Department of Physiology & Membrane Biology, University of California, Davis, CA 95616. ^[7] Department of Pharmacology, University of Washington, Seattle, WA 98195; scottjdw@uw.edu. ^[8]

关键词 AKAPs PKA kinase anchoring nucleus proximity labeling

主题词 A型激酶锚定蛋白质类(A Kinase Anchor Proteins);环AMP依赖性蛋白激酶类(Cyclic AMP-Dependent Protein Kinases);基因表达调控, 酶学(Gene Expression Regulation, Enzymologic);全基因组关联研究(Genome-Wide Association Study);人类(Humans);膜蛋白质类(Membrane Proteins);模型, 分子(Models, Molecular);多态性, 单核苷酸(Polymorphism, Single Nucleotide);蛋白质结合(Protein Binding);蛋白质构象(Protein Conformation);蛋白质亚型(Protein Isoforms);蛋白质转运(Protein Transport)

DOI 10.1073/pnas.1816614115

PMID 30455320

发布时间 2020-04-10

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2018年115卷49期

E11465-E11474页

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

2018年115卷49期

E11465-E11474页

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