Atropine counteracts the depressive-like behaviour elicited by acute exposure to commercial chlorpyrifos in rats.

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第一作者： Alciene Almeida,Siqueira

第一单位： Pharmaceutical Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil.

作者： Alciene Almeida,Siqueira ^[1] ; Alexandre Frinhani,Cunha ^[2] ; Graziany Leite Moreira,Marques ^[1] ; Igor Simões Assunção,Felippe ^[3] ; Vitor Sampaio,Minassa ^[4] ; Thallis Coelho da Silva,Gramelich ^[4] ; Maria Aparecida,Cicilini ^[5] ; Tamara Andrea,Alarcon ^[2] ; Rita Gomes Wanderley,Pires ^[6] ; Karla Nivea,Sampaio ^[7] ; Vanessa,Beijamini ^[8]

作者单位： Pharmaceutical Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil. ^[1] Biochemistry and Pharmacology Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil. ^[2] Pharmaceutical Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil; Department of Physiology, Faculty of Health & Medical Sciences, University of Auckland, Grafton Campus, Auckland 1023, New Zealand. ^[3] Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil. ^[4] Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-910, Brazil. ^[5] Department of Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-910, Brazil; Biochemistry and Pharmacology Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil. ^[6] Pharmaceutical Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil. ^[7] Pharmaceutical Sciences Graduate Program, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitoria, ES 29043-900, Brazil. Electronic address: vanessa.harres@ufes.br. ^[8]

关键词 Atropine Chlorpyrifos Cholinesterase Depression Forced swimming test Pralidoxime

主题词乙酰胆碱酯酶(Acetylcholinesterase);动物(Animals);解毒药(Antidotes);阿托品(Atropine);行为, 动物(Behavior, Animal);脑(Brain);毒死蜱(Chlorpyrifos);抑郁(Depression);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物疗法, 联合(Drug Therapy, Combination);男(雄)性(Male);解磷定化合物(Pralidoxime Compounds);大鼠(Rats);大鼠, Wistar(Rats, Wistar)

DOI 10.1016/j.ntt.2018.11.002

PMID 30458229

发布时间 2020-05-05

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Neurotoxicology and teratology

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Atropine counteracts the depressive-like behaviour elicited by acute exposure to commercial chlorpyrifos in rats.

Neurotoxicology and teratology

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Atropine counteracts the depressive-like behaviour elicited by acute exposure to commercial chlorpyrifos in rats.

Neurotoxicology and teratology

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Neurotoxicology and teratology

相关期刊

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