Evaluation of the genetic stability of Sabin strains and the consistency of inactivated poliomyelitis vaccine made from Sabin strains using direct deep-sequencing.

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第一作者： Yan,Deng

第一单位： Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infections Diseases, Kunming 650118, Yunnan, China. Electronic address: dy@imbcams.com.cn.

作者： Yan,Deng ^[1] ; Wei,Cai ^[2] ; Jinyan,Li ^[3] ; Ying,Li ^[4] ; Xiaolei,Yang ^[5] ; Yan,Ma ^[6] ; Yufeng,Yao ^[7] ; Lujie,Yang ^[8] ; Li,Shi ^[9] ; Mingbo,Sun ^[10]

作者单位： Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infections Diseases, Kunming 650118, Yunnan, China. Electronic address: dy@imbcams.com.cn. ^[1] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infections Diseases, Kunming 650118, Yunnan, China. Electronic address: caiwei@imbcams.com.cn. ^[2] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China. Electronic address: lijingyan@imbcams.com.cn. ^[3] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China. Electronic address: yingli@imbcams.com.cn. ^[4] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infections Diseases, Kunming 650118, Yunnan, China. Electronic address: yxl@imbcams.com.cn. ^[5] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infections Diseases, Kunming 650118, Yunnan, China. Electronic address: mayan2519@imbcams.com.cn. ^[6] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China. Electronic address: yufeng_yao@imbcams.com.cn. ^[7] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infections Diseases, Kunming 650118, Yunnan, China. Electronic address: yanglujie@imbcams.com.cn. ^[8] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China. Electronic address: shili@imbcams.com.cn. ^[9] Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan, China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infections Diseases, Kunming 650118, Yunnan, China. Electronic address: smb@imbcams.com.cn. ^[10]

关键词 Direct deep-sequencing Genetic stability Sabin strain sIPV