换一批
换一批Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder.
第一作者：
Ditte,Demontis
第一单位：
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.;Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.
作者：
Ditte,Demontis [1]
;
Raymond K,Walters [2]
;
Joanna,Martin [3]
;
Manuel,Mattheisen [4]
;
Thomas D,Als [1]
;
Esben,Agerbo [5]
;
Gísli,Baldursson [6]
;
Rich,Belliveau [7]
;
Jonas,Bybjerg-Grauholm [8]
;
Marie,Bækvad-Hansen [8]
;
Felecia,Cerrato [7]
;
Kimberly,Chambert [7]
;
Claire,Churchhouse [9]
;
Ashley,Dumont [7]
;
Nicholas,Eriksson [10]
;
Michael,Gandal [11]
;
Jacqueline I,Goldstein [9]
;
Katrina L,Grasby [12]
;
Jakob,Grove [13]
;
Olafur O,Gudmundsson [14]
;
Christine S,Hansen [15]
;
Mads Engel,Hauberg [1]
;
Mads V,Hollegaard [8]
;
Daniel P,Howrigan [2]
;
Hailiang,Huang [2]
;
Julian B,Maller [16]
;
Alicia R,Martin [9]
;
Nicholas G,Martin [12]
;
Jennifer,Moran [7]
;
Jonatan,Pallesen [1]
;
Duncan S,Palmer [2]
;
Carsten Bøcker,Pedersen [5]
;
Marianne Giørtz,Pedersen [5]
;
Timothy,Poterba [9]
;
Jesper Buchhave,Poulsen [8]
;
Stephan,Ripke [17]
;
Elise B,Robinson [18]
;
F Kyle,Satterstrom [9]
;
Hreinn,Stefansson [19]
;
Christine,Stevens [7]
;
Patrick,Turley [2]
;
G Bragi,Walters [20]
;
Hyejung,Won [21]
;
Margaret J,Wright [22]
;
ADHD Working Group of the Psychiatric Genomics Consortium (PGC) [23]
;
Early Lifecourse & Genetic Epidemiology (EAGLE) Consortium [24]
;
23andMe Research Team [25]
;
Ole A,Andreassen [26]
;
Philip,Asherson [27]
;
Christie L,Burton [28]
;
Dorret I,Boomsma [29]
;
Bru,Cormand [30]
;
Søren,Dalsgaard [31]
;
Barbara,Franke [32]
;
Joel,Gelernter [33]
;
Daniel,Geschwind [34]
;
Hakon,Hakonarson [24]
;
Jan,Haavik [35]
;
Henry R,Kranzler [36]
;
Jonna,Kuntsi [37]
;
Kate,Langley [38]
;
Klaus-Peter,Lesch [39]
;
Christel,Middeldorp [40]
;
Andreas,Reif [25]
;
Luis Augusto,Rohde [41]
;
Panos,Roussos [42]
;
Russell,Schachar [43]
;
Pamela,Sklar [44]
;
Edmund J S,Sonuga-Barke [10]
;
Patrick F,Sullivan [45]
;
Anita,Thapar [12]
;
Joyce Y,Tung [20]
;
Irwin D,Waldman [46]
;
Sarah E,Medland [8]
;
Kari,Stefansson [47]
;
Merete,Nordentoft [48]
;
David M,Hougaard [49]
;
Thomas,Werge [50]
;
Ole,Mors [51]
;
Preben Bo,Mortensen [52]
;
Mark J,Daly [53]
;
Stephen V,Faraone ;
Anders D,Børglum ;
Benjamin M,Neale
作者单位：
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.;Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.
[1]
Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[2]
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.;MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, UK.
[3]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.;Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.;Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.;Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.;Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany.
[4]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.;Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
[5]
Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland.
[6]
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[7]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
[8]
Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[9]
23andMe, Inc, Mountain View, CA, USA.
[10]
Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.;Center for Autism Research and Treatment and Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.;Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.;Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
[11]
QIMR Berghofer Medical Research Institute, Brisbane, Australia.
[12]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.;Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark.;Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
[13]
Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland.;deCODE genetics/Amgen, Reykjavík, Iceland.;Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
[14]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.;Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.
[15]
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Genomics plc, Oxford, UK.
[16]
Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
[17]
Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Department of Epidemiology, Harvard Chan School of Public Health, Boston, MA, USA.
[18]
deCODE genetics/Amgen, Reykjavík, Iceland.
[19]
deCODE genetics/Amgen, Reykjavík, Iceland.;Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
[20]
Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.;Center for Autism Research and Treatment and Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
[21]
Queensland Brain Institute, University of Queensland, Brisbane, Australia.
[22]
NORMENT KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway.
[23]
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
[24]
Psychiatry, Neurosciences and Mental Health, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
[25]
Department of Biological Psychology, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands.;EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.
[26]
Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Catalonia, Spain.;Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.;Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Catalonia, Spain.;Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Catalonia, Spain.
[27]
National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
[28]
Departments of Human Genetics (855) and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.
[29]
Department of Psychiatry, Genetics, and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.;Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.
[30]
Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.;Center for Autism Research and Treatment and Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.;Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
[31]
The Center for Applied Genomics, The Children´s Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[32]
K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway.;Haukeland University Hospital, Bergen, Norway.
[33]
Department of Psychiatry, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Veterans Integrated Service Network (VISN4) Mental Illness Research, Education, and Clinical Center (MIRECC), Crescenz VA Medical Center, Philadephia, PA, USA.
[34]
MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, UK.;School of Psychology, Cardiff University, Cardiff, UK.
[35]
Division of Molecular Psychiatry, Center of Mental Health, University of Wuerzburg, Wuerzburg, Germany.;Department of Neuroscience, School for Mental Health and Neuroscience (MHENS), Maastricht University, Maastricht, The Netherlands.;Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
[36]
Department of Biological Psychology, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands.;Child Health Research Centre, University of Queensland, Brisbane, Australia.;Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.
[37]
Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
[38]
Department of Psychiatry, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.;ADHD Outpatient Clinic, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
[39]
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Friedman Brain Institute, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Mental Illness Research Education and Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, New York, USA.
[40]
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Institute for Genomics and Multiscale Biology, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Friedman Brain Institute, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[41]
Institute of Psychiatry, Psychology & Neuroscience, Kings College, London, UK.
[42]
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.;Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
[43]
MRC Centre for Neuropsychiatric Genetics & Genomics, School of Medicine, Cardiff University, Cardiff, UK.
[44]
Department of Psychology, Emory University, Atlanta, GA, USA.
[45]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
[46]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark.;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
[47]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark.
[48]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.;Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.;National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.;Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark.
[49]
Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland.
[50]
Departments of Psychiatry and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. sfaraone@childpsychresearch.org.
[51]
The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. anders@biomed.au.dk.;Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark. anders@biomed.au.dk.;Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark. anders@biomed.au.dk.
[52]
Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. bneale@broadinstitute.org.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. bneale@broadinstitute.org.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. bneale@broadinstitute.org.
[53]
主题词
青少年(Adolescent);注意力缺陷障碍伴多动(Attention Deficit Disorder with Hyperactivity);脑(Brain);儿童(Child);儿童, 学龄前(Child, Preschool);队列研究(Cohort Studies);女(雌)性(Female);基因表达调控(Gene Expression Regulation);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);人类(Humans);男(雄)性(Male);多态性, 单核苷酸(Polymorphism, Single Nucleotide);危险(Risk)
DOI
10.1038/s41588-018-0269-7
PMID
30478444
发布时间
2023-03-22
- 浏览17
Nature genetics
Nature genetics
63-75页
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