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首页> International journal of oncology> Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation.

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation.

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作者： Laura,Antonucci ^[1] ; Laura,Di Magno ^[2] ; Davide,D'Amico ^[1] ; Simona,Manni ^[1] ; Silvia Maria,Serrao ^[1] ; Fiorella,Di Pastena ^[3] ; Rosa,Bordone ^[1] ; Zuleyha Nihan,Yurtsever ^[4] ; Miriam,Caimano ^[1] ; Marialaura,Petroni ^[2] ; Alessandra,Giorgi ^[4] ; Maria Eugenia,Schininà ^[4] ; John R,Yates Iii ^[5] ; Lucia,Di Marcotullio ^[1] ; Enrico,De Smaele ^[6] ; Saula,Checquolo ^[3] ; Carlo,Capalbo ^[1] ; Enzo,Agostinelli ^[4] ; Marella,Maroder ^[3] ; Sonia,Coni ^[1] ; Gianluca,Canettieri ^[1]

作者单位： Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy. ^[1] Center for Life Nano Science at Sapienza, Italian Institute of Technology, 00161 Rome, Italy. ^[2] Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy. ^[3] Department of Biochemical Sciences 'A. Rossi Fanelli', Sapienza University of Rome, 00161 Rome, Italy. ^[4] Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. ^[5] Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy. ^[6]

关键词 hedgehog medulloblastoma GLI1 mitogen-activated kinase kinase kinase 1 phosphorylation

主题词酰苯胺类(Anilides);动物(Animals);细胞增殖(Cell Proliferation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);猬蛋白质类(Hedgehog Proteins);人类(Humans);MAP激酶激酶激酶1(MAP Kinase Kinase Kinase 1);髓母细胞瘤(Medulloblastoma);小鼠(Mice);NIH 3T3细胞(NIH 3T3 Cells);磷酰化(Phosphorylation);吡啶类(Pyridines);RNA, 信使(RNA, Messenger);信号传导(Signal Transduction);转录因子(Transcription Factors)

DOI 10.3892/ijo.2018.4638

PMID 30483764

发布时间 2021-12-01

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International journal of oncology

International journal of oncology

2019年54卷2期

505-514页

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