Mutation in <i>LBX1/Lbx1</i> precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice.

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第一作者： Luis Rodrigo,Hernandez-Miranda

第一单位： Developmental Biology and Signal Transduction Group, Max-Delbrueck-Centrum in the Helmholtz Association, 13125 Berlin, Germany.

作者： Luis Rodrigo,Hernandez-Miranda ^[1] ; Daniel M,Ibrahim ^[2] ; Pierre-Louis,Ruffault ^[3] ; Madeleine,Larrosa ^[1] ; Kira,Balueva ^[1] ; Thomas,Müller ^[1] ; Willemien de,Weerd ^[4] ; Irene,Stolte-Dijkstra ^[5] ; Robert M W,Hostra ^[5] ; Jean-François,Brunet ^[6] ; Gilles,Fortin ^[7] ; Stefan,Mundlos ^[2] ; Carmen,Birchmeier ^[8]

作者单位： Developmental Biology and Signal Transduction Group, Max-Delbrueck-Centrum in the Helmholtz Association, 13125 Berlin, Germany. ^[1] Development and Disease Group, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.;Institute for Medical and Human Genetics, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany. ^[2] Developmental Biology and Signal Transduction Group, Max-Delbrueck-Centrum in the Helmholtz Association, 13125 Berlin, Germany.;Hindbrain Integrative Neurobiology Group, Paris-Saclay Institute for Neuroscience, UMR9197/CNRS, 91190 Gif sur Yvette, France. ^[3] Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. ^[4] Department of Clinical Genetics, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands. ^[5] Institut de Biologie, École Normale Supérieure, 75005 Paris, France. ^[6] Hindbrain Integrative Neurobiology Group, Paris-Saclay Institute for Neuroscience, UMR9197/CNRS, 91190 Gif sur Yvette, France. ^[7] Developmental Biology and Signal Transduction Group, Max-Delbrueck-Centrum in the Helmholtz Association, 13125 Berlin, Germany; cbirch@mdc-berlin.de. ^[8]

关键词 LBX1/Lbx1 Phox2b congenital hypoventilation neuronal fate change transcriptional cooperativity