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Blocking LC3 lipidation and ATG12 conjugation reactions by ATG7 mutant protein containing C572S.

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第一作者： Akari,Nitta

第一单位： The Aoki Laboratory, Life Science Unit, Tenure-Track Program for Innovative Research, University of Fukui 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan; Department of Pharmacology, Unit of Biochemistry and Bioinformative Sciences, Faculty of Medicine, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.

作者： Akari,Nitta ^[1] ; Kazuya,Hori ^[2] ; Isei,Tanida ^[3] ; Ayumi,Igarashi ^[1] ; Yasuyo,Deyama ^[4] ; Takashi,Ueno ^[5] ; Eiki,Kominami ^[6] ; Manabu,Sugai ^[7] ; Koji,Aoki ^[8]

作者单位： The Aoki Laboratory, Life Science Unit, Tenure-Track Program for Innovative Research, University of Fukui 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan; Department of Pharmacology, Unit of Biochemistry and Bioinformative Sciences, Faculty of Medicine, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan. ^[1] Department of Pharmacology, Unit of Biochemistry and Bioinformative Sciences, Faculty of Medicine, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan. ^[2] Department of Cell Biology and Neuroscience, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. ^[3] The Aoki Laboratory, Life Science Unit, Tenure-Track Program for Innovative Research, University of Fukui 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan. ^[4] Laboratory of Proteomics and Biomolecular Science, Research Support Center, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. ^[5] Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. ^[6] Department of Molecular Genetics, Unit of Biochemistry and Bioinformative Sciences, Faculty of Medicine, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan. ^[7] The Aoki Laboratory, Life Science Unit, Tenure-Track Program for Innovative Research, University of Fukui 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan; Department of Pharmacology, Unit of Biochemistry and Bioinformative Sciences, Faculty of Medicine, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan; Life Science Innovation Center, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan; PREST, Japan Science and Technology Agency, 5-7 Chiyoda-ku, Tokyo, 102-0076, Japan. Electronic address: aokik@u-fukui.ac.jp. ^[8]

关键词 ATG12 conjugation ATG7 Autophagosome Autophagy LC3 lipidation

医学主题词自噬(Autophagy);细胞, 培养的(Cells, Cultured);人类(Humans);突变蛋白质类(Mutant Proteins);磷脂酰乙醇胺类(Phosphatidylethanolamines)

DOI 10.1016/j.bbrc.2018.11.158

PMID 30503495

发布时间 2023-12-13

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准确一般字义偏差语意偏离译文作用小提交