Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.

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作者： Jie,Gu ^[1] ; Wei,Mao ^[1] ; Wenjia,Ren ^[2] ; Fengkai,Xu ^[3] ; Qiaoliang,Zhu ^[3] ; Chunlai,Lu ^[3] ; Zongwu,Lin ^[3] ; Zhilong,Zhang ^[4] ; Yiwei,Chu ^[5] ; Ronghua,Liu ^[6] ; Di,Ge ^[7]

作者单位： Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, and Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, PR China. ^[1] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China. ^[2] Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China. ^[3] Department of Thoracic Surgery, Shanghai XuHui District Central Hospital, Shanghai, 200031, PR China. ^[4] Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, and Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, PR China. ^[5] Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, and Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, PR China. Electronic address: ronghualiu@fudan.edu.cn. ^[6] Department of Thoracic Surgery, The Affiliated Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China. Electronic address: gedi6902@hotmail.com. ^[7]

关键词 Cancer stem cell Non-small-cell lung cancer Ubiquitin-protein ligase E3C Ubiquitylation p53