Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multiparametric imaging.

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第一作者： Meng,Lu

第一单位： Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom; Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom.

作者： Meng,Lu ^[1] ; Neil,Williamson ^[2] ; Ajay,Mishra ^[1] ; Claire H,Michel ^[2] ; Clemens F,Kaminski ^[1] ; Alan,Tunnacliffe ^[3] ; Gabriele S,Kaminski Schierle ^[4]

作者单位： Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom; Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom. ^[1] Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom. ^[2] Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom. ^[3] Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom; Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom. Electronic address: gsk20@cam.ac.uk. ^[4]

关键词 3D structure of amyloid aggregates Alzheimer's disease Arctic mutant SIM amyloid-β amyloid-β (Aβ)microscopic imaging molecular dynamics neurodegeneration protein aggregation structural model