Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.-论文-万方医学网

作者： Yudong,Liu ^[1] ; Yaíma L,Lightfoot ^[1] ; Nickie,Seto ^[1] ; Carmelo,Carmona-Rivera ^[1] ; Erica,Moore ^[1] ; Rishi,Goel ^[1] ; Liam,O'Neil ^[1] ; Pragnesh,Mistry ^[1] ; Victoria,Hoffmann ^[2] ; Santanu,Mondal ^[3] ; Padmavathy Nandha,Premnath ^[3] ; Katherine,Gribbons ^[1] ; Stefania,Dell'Orso ^[4] ; Kan,Jiang ^[4] ; Paul R,Thompson ^[3] ; Hong-Wei,Sun ^[4] ; Scott A,Coonrod ^[5] ; Mariana J,Kaplan ^[1]

作者单位： Systemic Autoimmunity Branch, Intramural Research Program (IRP), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and. ^[1] Division of Veterinary Resources, Office of the Director, NIH, Bethesda, Maryland, USA. ^[2] University of Massachusetts School of Medicine, Worcester, Massachusetts, USA. ^[3] Biodata Mining and Discovery Section, Office of Science and Technology, IRP, NIAMS/ NIH, Bethesda, Maryland, USA. ^[4] Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA. ^[5]

主题词适应性免疫(Adaptive Immunity);动物(Animals);自身免疫疾病(Autoimmune Diseases);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);基因表达调控(Gene Expression Regulation);组蛋白类(Histones);人类(Humans);水解酶类(Hydrolases);免疫, 先天(Immunity, Innate);炎症(Inflammation);干扰素Ⅰ型(Interferon Type I);红斑狼疮, 系统性(Lupus Erythematosus, Systemic);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);T淋巴细胞(T-Lymphocytes);Th1细胞(Th1 Cells);Th17细胞(Th17 Cells);Toll样受体7(Toll-Like Receptor 7)

DOI 10.1172/jci.insight.124729

PMID 30518690

发布时间 2020-03-09

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Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.

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Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.

JCI insight

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