换一批Hepatic cell sheets engineered from human mesenchymal stem cells with a single small molecule compound IC-2 ameliorate acute liver injury in mice.
第一作者：
Noriko,Itaba
第一单位：
Division of Molecular and Genetic Medicine, Graduate School of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.
作者：
关键词
8-OHdG, 8-hydroxydeoxyguanosineA1AT, α1-antitrypsinALT, alanine aminotransferaseAPOE, apolipoprotein EAREG, amphiregulinAST, aspartate aminotransferaseAcute liver failureBM-MSCs, bone marrow-derived mesenchymal stem cellsC3, complement C3C4A, complement C4AC5aR, complement C5a receptorCBP, CREB-binding proteinCCl4, carbon tetrachlorideCP, ceruloplasminChREBP, Carbohydrate-responsive element-binding proteinChoREs, carbohydrate response elementsDMSO, dimethyl sulfoxideEGFR, epidermal growth factor receptorERK, extracellular signal-regulated kinaseGPX, glutathione peroxidaseGR, Glutathione reductaseGRX, glutaredoxinGSH, glutathioneHB-EGF, heparin binding-epidermal growth factor-like growth factorHGFR, hepatocyte growth factor receptorHepatic cell sheetsIL-1ra, interleukin-1 receptor antagonistIL-6, interleukin-6LXR, liver X receptorLiver regenerationMDA, malondialdehydeMesenchymal stem cellsNF-κB, nuclear factor-kappa BPCNA, proliferating cell nuclear antigenPRX, peroxiredoxinRBP4, retinol binding protein 4SOD, superoxide dismutaseSTAT-3, Signal Tranducer and Activator of Transcription 3TF, transferrinTGFα, transforming growth factor alphaTNFα, tumor necrosis factor alphaTRX, thioredoxinTRXR, thioredoxin reductaseWnt/β-catenin signal inhibitorhGAPDH, human glyceraldehyde 3-phosphate dehydrogenasemActb, mouse actin, beta
DOI
10.1016/j.reth.2018.07.001
PMID
30525075
发布时间
2024-04-03
- 浏览3
Regenerative therapy
2018年9卷
45-57页
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