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Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.

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第一作者： Noga,Ron-Harel

第一单位： Department of Cell Biology, Harvard Medical School, Boston, MA 02115.

作者： Noga,Ron-Harel ^[1] ; Giulia,Notarangelo ^[1] ; Jonathan M,Ghergurovich ^[2] ; Joao A,Paulo ^[1] ; Peter T,Sage ^[3] ; Daniel,Santos ^[4] ; F Kyle,Satterstrom ^[5] ; Steven P,Gygi ^[1] ; Joshua D,Rabinowitz ^[6] ; Arlene H,Sharpe ^[7] ; Marcia C,Haigis ^[8]

作者单位： Department of Cell Biology, Harvard Medical School, Boston, MA 02115. ^[1] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.;Department of Molecular Biology, Princeton University, Princeton, NJ 08544. ^[2] Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. ^[3] Department of Cell Biology, Harvard Medical School, Boston, MA 02115.;Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-504, Portugal. ^[4] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142.;Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114. ^[5] Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544.;Department of Chemistry, Princeton University, Princeton, NJ 08544. ^[6] Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.;Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.;Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115. ^[7] Department of Cell Biology, Harvard Medical School, Boston, MA 02115; marcia_haigis@hms.harvard.edu. ^[8]

关键词 T cells aging metabolism mitochondria one-carbon metabolism