Effect of Mexiletine on Muscle Stiffness in Patients With Nondystrophic Myotonia Evaluated Using Aggregated N-of-1 Trials.

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作者： Bas C,Stunnenberg ^[1] ; Joost,Raaphorst ^[1] ; Hans M,Groenewoud ^[2] ; Jeffrey M,Statland ^[3] ; Robert C,Griggs ^[4] ; Willem,Woertman ^[5] ; Dick F,Stegeman ^[3] ; Janneke,Timmermans ^[1] ; Jaya,Trivedi ^[6] ; Emma,Matthews ^[7] ; Christiaan G J,Saris ^[8] ; Bas J,Schouwenberg ^[1] ; Gea,Drost ^[9] ; Baziel G M,van Engelen ^[10] ; Gert Jan,van der Wilt ^[1]

作者单位： Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands. ^[1] Department of Neurology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands. ^[2] Department of Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands. ^[3] Department of Neurology, University of Kansas Medical Center, Kansas City. ^[4] Department of Neurology, University of Rochester Medical Center, Rochester, New York. ^[5] Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands. ^[6] Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas. ^[7] MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, United Kingdom. ^[8] Department of Pharmacology-Toxicology, Radboud University Medical Center, Nijmegen, the Netherlands. ^[9] University of Groningen, Department of Neurology and Neurosurgery, University Medical Center Groningen, Groningen, the Netherlands. ^[10]