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Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis.

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第一作者: Yael,Haberman
第一单位: Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA. Yael.haberman@cchmc.org.
作者单位: Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA. Yael.haberman@cchmc.org. [1] Sheba Medical Center, Tel-HaShomer, affiliated with the Tel-Aviv University, Tel-Aviv, Israel. Yael.haberman@cchmc.org. [2] The Broad Institute of MIT and Harvard, Cambridge, MA, USA. [3] Harvard T.H. Chan School of Public Health, Boston, MA, USA. [4] Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA. [5] Sheba Medical Center, Tel-HaShomer, affiliated with the Tel-Aviv University, Tel-Aviv, Israel. [6] Hospital for Sick Children, University of Toronto, Toronto, ON, Canada. [7] The Children's Hospital of Philadelphia, Philadelphia, PA, USA. [8] Medical College of Wisconsin, Milwaukee, WI, USA. [9] Goryeb Children's Hospital/Atlantic Health, Morristown, NJ, USA. [10] Cohen Children's Medical Center of New York, New Hyde Park, New York, NY, USA. [11] Nationwide Children's Hospital, Columbus, OH, USA. [12] Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada. [13] University of California San Francisco, San Francisco, CA, USA. [14] University at Buffalo, Buffalo, NY, USA. [15] Texas Children's Hospital, Baylor College School of Medicine, Houston, TX, USA. [16] Vanderbilt Children's Hospital, Nashville, TN, USA. [17] UT Southwestern Medical Center at Dallas, Dallas, TX, USA. [18] University of North Carolina, Chapel Hill, NC, USA. [19] Riley Children's Hospital, Indiannapolis, IN, USA. [20] Hasbro Children's Hospital, Providence, RI, USA. [21] IWK Health Centre, Halifax, NS, Canada. [22] John Hopkins University, Baltimore, MD, USA. [23] Cedars-Sinai Medical Center, Los Angeles, CA, USA. [24] University of Chicago Comer Children's Hospital, Chicago, IL, USA. [25] Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA. [26] University of Utah, Salt Lake City, UT, USA. [27] Children's Center for Digestive HealthMedicine, Atlanta, GA, USA. [28] Children's Hospital - Boston, Boston, MA, USA. [29] Nemours Children's Clinic, Jacksonville, FL, USA. [30] Mount Sinai Hospital New York, New York, NY, USA. [31] Connecticut Children's Medical Center, Hartford, CT, USA. [32] Emory University, Atlanta, GA, USA. [33] Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. [34]
DOI 10.1038/s41385-018-0114-4
PMID 30542108
发布时间 2023-02-03
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