A Ruthenium(II) N-Heterocyclic Carbene (NHC) Complex with Naphthalimide Ligand Triggers Apoptosis in Colorectal Cancer Cells via Activating the ROS-p38 MAPK Pathway.

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作者： Yasamin,Dabiri ^[1] ; Alice,Schmid ^[2] ; Jannick,Theobald ^[3] ; Biljana,Blagojevic ^[4] ; Wojciech,Streciwilk ^[5] ; Ingo,Ott ^[6] ; Stefan,Wölfl ^[7] ; Xinlai,Cheng ^[8]

作者单位： Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. dabiri@stud.uni-heidelberg.de. ^[1] Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. alice.schmid@stud.uni-heidelberg.de. ^[2] Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. jannick.theobald@gmail.com. ^[3] Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. blagojevic@stud.uni-heidelberg.de. ^[4] Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany. w.streciwilk@tu-bs.de. ^[5] Institute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany. ingo.ott@tu-bs.de. ^[6] Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. wolfl@uni-hd.de. ^[7] Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany. x.cheng@uni-heidelberg.de. ^[8]

关键词 N-heterocyclic carbene ROS apoptosis cancer mitochondria naphthalimide-metal complex conjugates p38 MAPK