USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages.

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第一作者： Maija,Ruuth

第一单位： Wihuri Research Institute, FI-00290, Helsinki, Finland.;Research Program Unit, University of Helsinki, FI-00014, Helsinki, Finland.

作者： Maija,Ruuth ^[1] ; Jarkko,Soronen ^[2] ; Essi,Kaiharju ^[3] ; Krista,Merikanto ^[3] ; Julia,Perttilä ^[4] ; Jari,Metso ^[3] ; Miriam,Lee-Rueckert ^[5] ; Marja-Riitta,Taskinen ^[6] ; Petri T,Kovanen ^[5] ; Katariina,Öörni ^[5] ; Vesa M,Olkkonen ^[7] ; Matti S,Jauhiainen ^[8] ; Pirkka-Pekka,Laurila ^[9]

作者单位： Wihuri Research Institute, FI-00290, Helsinki, Finland.;Research Program Unit, University of Helsinki, FI-00014, Helsinki, Finland. ^[1] Genomics and Biomarkers Unit, National Institute for Health and Welfare, FI-00251, Helsinki, Finland.;Minerva Foundation Institute for Medical Research, Tukholmankatu 8, 00290, Helsinki, Finland. ^[2] Genomics and Biomarkers Unit, National Institute for Health and Welfare, FI-00251, Helsinki, Finland. ^[3] Minerva Foundation Institute for Medical Research, Tukholmankatu 8, 00290, Helsinki, Finland. ^[4] Wihuri Research Institute, FI-00290, Helsinki, Finland. ^[5] Diabetes and Obesity Research Program, University of Helsinki, FI-00014, Helsinki, Finland. ^[6] Minerva Foundation Institute for Medical Research, Tukholmankatu 8, 00290, Helsinki, Finland.;Department of Anatomy, Faculty of Medicine, University of Helsinki, FI-00014, Helsinki, Finland. ^[7] Genomics and Biomarkers Unit, National Institute for Health and Welfare, FI-00251, Helsinki, Finland. matti.jauhiainen@thl.fi.;Minerva Foundation Institute for Medical Research, Tukholmankatu 8, 00290, Helsinki, Finland. matti.jauhiainen@thl.fi. ^[8] Genomics and Biomarkers Unit, National Institute for Health and Welfare, FI-00251, Helsinki, Finland.;Department of Medical and Clinical Genetics, University of Helsinki, FI-00014, Helsinki, Finland.;Institute for Molecular Medicine Finland, FIMM, FI-00251, Helsinki, Finland. ^[9]

关键词 Cholesterol accumulation Cholesterol efflux Hepatocyte High density lipoproteins Inflammation Macrophage USF1