Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity.

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第一作者： Essam A,Assali

第一单位： Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.;Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

作者： Essam A,Assali ^[1] ; Dovi,Shlomo ^[2] ; Jialiu,Zeng ^[3] ; Evan P,Taddeo ^[4] ; Kyle M,Trudeau ^[5] ; Karel A,Erion ^[4] ; Aaron H,Colby ^[6] ; Mark W,Grinstaff ^[3] ; Marc,Liesa ^[7] ; Guy,Las ^[2] ; Orian S,Shirihai ^[1]

作者单位： Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.;Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. ^[1] Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel. ^[2] Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA.;Department of Chemistry, Boston University, Boston, Massachusetts, USA.;Department of Medicine, Boston University, Boston, Massachusetts, USA. ^[3] Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. ^[4] Obesity and Nutrition Section, Department of Medicine, Evans Biomedical Research Center, Boston University School of Medicine, Boston, Massachusetts, USA. ^[5] Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA. ^[6] Division of Endocrinology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.;Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.;Molecular Biology Institute, University of California, Los Angeles, Los Angeles, California, USA. ^[7]

关键词 autophagy bioenergetics free fatty acids islets photoactivated nanoparticles