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Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages.

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第一作者： Xiaokang,Zeng

第一单位： The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China.

作者： Xiaokang,Zeng ^[1] ; Guangao,Liu ^[1] ; Wanwen,Peng ^[1] ; Junming,He ^[1] ; Chenxu,Cai ^[2] ; Wei,Xiong ^[2] ; Shasha,Chen ^[2] ; Meixiang,Yang ^[3] ; Zhongjun,Dong ^[4]

作者单位： The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China. ^[1] Institute for Immunology and School of Medicine, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, 100086, Beijing, China. ^[2] The First Affiliated Hospital, Biomedical Translational Research Institute, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, China. yangmxqilu@163.com. ^[3] Institute for Immunology and School of Medicine, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, 100086, Beijing, China. dongzj@biomed.tsinghua.edu.cn. ^[4]

关键词 Liver inflammation MAPK Macrophage Nonclassical SLAM family receptors TLR4