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首页> Journal of controlled release : official journal of the Controlled Release Society> Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs.

Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs.

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作者： Camilla Kaas,Frich ^[1] ; Franziska,Krüger ^[2] ; Raoul,Walther ^[1] ; Cecilie,Domar ^[1] ; Anna H F,Andersen ^[3] ; Anne,Tvilum ^[1] ; Frederik,Dagnæs-Hansen ^[4] ; Paul W,Denton ^[3] ; Martin,Tolstrup ^[3] ; Søren R,Paludan ^[4] ; Jan,Münch ^[5] ; Alexander N,Zelikin ^[6]

作者单位： Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark. ^[1] Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. ^[2] Department of Infectious Diseases, Aarhus University Hospital, 8000 Aarhus C, Denmark; Department of Clinical Medicine, Aarhus University, 8000 Aarhus N, Denmark. ^[3] Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark. ^[4] Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. Electronic address: Jan.Muench@uni-ulm.de. ^[5] Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark. Electronic address: zelikin@chem.au.dk. ^[6]

关键词 Acyclovir Albumin Herpes simplex virus Macromolecular prodrugs

主题词阿昔洛韦(Acyclovir);白蛋白类(Albumins);动物(Animals);抗病毒药(Antiviral Agents);女(雌)性(Female);单纯疱疹(Herpes Simplex);疱疹病毒2型, 人(Herpesvirus 2, Human);人类(Humans);注射, 皮下(Injections, Subcutaneous);小鼠, 近交BALB C(Mice, Inbred BALB C);磷脂酰甘油类(Phosphatidylglycerols);聚乙烯二醇类(Polyethylene Glycols);聚甲基丙烯酸类(Polymethacrylic Acids);药物前体(Prodrugs);阴道冲洗(Vaginal Douching)

DOI 10.1016/j.jconrel.2018.12.016

PMID 30552954

发布时间 2020-03-20

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Journal of controlled release

298-310页

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