Revival of a potent therapeutic maytansinoid agent using a strategy that combines covalent drug conjugation with sequential nanoparticle assembly.

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作者： Ke,Xie ^[1] ; Shanshan,Song ^[2] ; Liqian,Zhou ^[1] ; Jianqin,Wan ^[1] ; Yiting,Qiao ^[1] ; Min,Wang ^[2] ; Haiyang,Xie ^[1] ; Lin,Zhou ^[1] ; Shusen,Zheng ^[3] ; Hangxiang,Wang ^[4]

作者单位： The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou 310003, PR China. ^[1] Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, PR China. ^[2] The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou 310003, PR China. Electronic address: shusenzheng@zju.edu.cn. ^[3] The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, School of Medicine, Zhejiang University, Hangzhou 310003, PR China. Electronic address: wanghx@zju.edu.cn. ^[4]

关键词 Cancer nanomedicine Drug toxicity Maytansinoid Polymeric prodrug Self-assembly