Assessing copy number aberrations and copy-neutral loss-of-heterozygosity across the genome as best practice: An evidence-based review from the Cancer Genomics Consortium (CGC) working group for chronic lymphocytic leukemia.

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第一作者： Kathy,Chun

第一单位： Genetics Program, North York General Hospital, Toronto, ON, Canada. Electronic address: patricia.miron@umassmemorial.org.

作者： Kathy,Chun ^[1] ; Gail D,Wenger ^[2] ; Alka,Chaubey ^[3] ; D P,Dash ^[4] ; Rashmi,Kanagal-Shamanna ^[5] ; Sibel,Kantarci ^[6] ; Ravindra,Kolhe ^[7] ; Daniel L,Van Dyke ^[8] ; Lu,Wang ^[9] ; Daynna J,Wolff ^[10] ; Patricia M,Miron ^[11]

作者单位： Genetics Program, North York General Hospital, Toronto, ON, Canada. Electronic address: patricia.miron@umassmemorial.org. ^[1] Cytogenetics Laboratory, Penrose St. Francis/Centura Health, Colorado Springs, CO, USA. ^[2] Greenwood Genetic Center, Greenwood, SC, USA. ^[3] Blood Center of Wisconsin, Milwaukee, WI, USA. ^[4] Department of Hematopathology and Molecular Diagnostics, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA. ^[5] Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, USA. ^[6] Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA. ^[7] Genomics Laboratory, Mayo Clinic, Rochester, MN USA. ^[8] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[9] Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA. ^[10] Department of Pathology, UMassMemorial Medical Center, Worcester, MA, USA; Quest Diagnostics, Marlborough, MA, USA. Electronic address: patricia.miron@umassmemorial.org. ^[11]

关键词 Chromosomal microarray analysis (CMA)Chronic lymphocytic leukemia (CLL)Copy number alterations (CNAs)Copy-neutral loss-of-heterozygosity (CN-LOH)Cytogenetics Fluorescence in situ hybridization (FISH)

主题词 DNA拷贝数变异(DNA Copy Number Variations);循证医学(Evidence-Based Medicine);人类(Humans);白血病, 淋巴细胞, 慢性, B细胞(Leukemia, Lymphocytic, Chronic, B-Cell);杂合子丢失(Loss of Heterozygosity)

DOI 10.1016/j.cancergen.2018.07.004

PMID 30554732

发布时间 2019-04-29

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