Stevioside inhibits experimental fibrosis by down-regulating profibrotic Smad pathways and blocking hepatic stellate cell activation.
第一作者:
Sael,Casas-Grajales
第一单位:
Department of Pharmacology, Cinvestav-IPN, Mexico City, Mexico.
作者:
主题词
肌动蛋白类(Actins);动物(Animals);细胞系(Cell Line);胶原Ⅰ型(Collagen Type I);胶原酶类(Collagenases);脱氧胞苷核苷酸类(Deoxycytosine Nucleotides);二萜类, 贝壳杉烷(Diterpenes, Kaurane);减量调节(Down-Regulation);纤维化(Fibrosis);葡糖苷类(Glucosides);肝星状细胞(Hepatic Stellate Cells);人类(Humans);肝(Liver);肝硬化(Liver Cirrhosis);淋巴因子(Lymphokines);MAP激酶信号系统(MAP Kinase Signaling System);男(雄)性(Male);血小板源性生长因子(Platelet-Derived Growth Factor);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc);大鼠(Rats);大鼠, Wistar(Rats, Wistar);信号传导(Signal Transduction);Smad蛋白质类(Smad Proteins);硫代乙酰胺(Thioacetamide);转化生长因子β1(Transforming Growth Factor beta1);增量调节(Up-Regulation)
DOI
10.1111/bcpt.13194
PMID
30561898
发布时间
2020-06-01
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