Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.

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作者： Danqi,Chen ^[1] ; Yuehong,Chen ^[2] ; Fulin,Lian ^[1] ; Liu,Chen ^[1] ; Yanlian,Li ^[1] ; Danyan,Cao ^[1] ; Xin,Wang ^[1] ; Lin,Chen ^[1] ; Jian,Li ^[1] ; Tao,Meng ^[1] ; Min,Huang ^[3] ; Meiyu,Geng ^[2] ; Jingkang,Shen ^[1] ; Naixia,Zhang ^[4] ; Bing,Xiong ^[5]

作者单位： Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. ^[1] Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. ^[2] Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. Electronic address: mhuang@simm.ac.cn. ^[3] Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. Electronic address: nxzhang@simm.ac.cn. ^[4] Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. Electronic address: bxiong@simm.ac.cn. ^[5]

关键词 Fragment-based Inhibitor PDEδ-RAS Protein-protein interaction