Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence.-论文-万方医学网

作者： Yoon-Dong,Park ^[1] ; Joseph N,Jarvis ^[2] ; Guowu,Hu ^[3] ; Sarah E,Davis ^[4] ; Jin,Qiu ^[5] ; Nannan,Zhang ^[5] ; Christopher,Hollingsworth ^[5] ; Angela,Loyse ^[5] ; Paul J,Gardina ^[5] ; Tibor,Valyi-Nagy ^[6] ; Timothy G,Myers ^[7] ; Thomas S,Harrison ^[8] ; Tihana,Bicanic ^[7] ; Peter R,Williamson ^[9]

作者单位： Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA yoon-dong.park@nih.gov williamsonpr@mail.nih.gov. ^[1] Botswana-UPenn Partnership, Gaborone, Botswana. ^[2] Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[3] Department of Clinical Research, Faculty of Infectious Diseases and Tropical Medicine, London School of Hygiene and Tropical Medicine, London, United Kingdom. ^[4] Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[5] Global Health Group, Department of Infection and Immunity, St. George's University of London, London, United Kingdom. ^[6] Genomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[7] Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA. ^[8] Institute of Infection and Immunity, St. George's University of London, London, United Kingdom. ^[9]

主题词成年人(Adult);动物(Animals);新型隐球菌(Cryptococcus neoformans);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);基因表达谱(Gene Expression Profiling);基因, 调节(Genes, Regulator);HIV感染(HIV Infections);宿主与病原体相互作用(Host-Pathogen Interactions);人类(Humans);男(雄)性(Male);膜转运蛋白质类(Membrane Transport Proteins);脑膜炎, 隐球菌性(Meningitis, Cryptococcal);代谢网络和途径(Metabolic Networks and Pathways);小鼠(Mice);小鼠, 近交CBA(Mice, Inbred CBA);中年人(Middle Aged);随机对照试验(主题)(Randomized Controlled Trials as Topic);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);毒力(Virulence);毒力因子类(Virulence Factors);青年人(Young Adult)

DOI 10.1128/mBio.02353-18

PMID 30563896

发布时间 2021-12-04

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Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence.

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Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence.

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