首页> Genes & development> Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.

Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination.

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第一作者： David M,Moquin

第一单位： Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

作者： David M,Moquin ^[1] ; Marie-Michelle,Genois ^[1] ; Jia-Min,Zhang ^[1] ; Jian,Ouyang ^[1] ; Tribhuwan,Yadav ^[1] ; Rémi,Buisson ^[1] ; Stephanie A,Yazinski ^[1] ; Jun,Tan ^[2] ; Myriam,Boukhali ^[1] ; Jean-Philippe,Gagné ^[3] ; Guy G,Poirier ^[3] ; Li,Lan ^[2] ; Wilhelm,Haas ^[4] ; Lee,Zou ^[5]

作者单位： Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA. ^[1] Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.;Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. ^[2] Centre de Recherche du CHU de Quebec, Laval University, Quebec, Quebec G1V 4G2, Canada. ^[3] Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.;Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. ^[4] Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.;Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. ^[5]

关键词 DNA damage response DNA end resection homologous recombination

医学主题词生物素化作用(Biotinylation);碳氮连接酶类(Carbon-Nitrogen Ligases);细胞系(Cell Line);DNA断裂, 双链(DNA Breaks, Double-Stranded);DNA损伤(DNA Damage);DNA修复(DNA Repair);DNA, 单链(DNA, Single-Stranded);DNA结合蛋白质类(DNA-Binding Proteins);大肠杆菌蛋白质类(Escherichia coli Proteins);基因敲低技术(Gene Knockdown Techniques);人类(Humans);蛋白质结合(Protein Binding);蛋白质转运(Protein Transport);阻遏蛋白质类(Repressor Proteins);转录因子(Transcription Factors);泛素蛋白连接酶类(Ubiquitin-Protein Ligases)

DOI 10.1101/gad.315978.118

PMID 30567999

发布时间 2020-04-08

基金项目

R01 GM118833/GM/NIGMS NIH HHS/United States R00 CA212154/CA/NCI NIH HHS/United States F31 GM067388/GM/NIGMS NIH HHS/United States K99 CA212154/CA/NCI NIH HHS/United States R01 GM076388/GM/NIGMS NIH HHS/United States R01 CA197779/CA/NCI NIH HHS/United States F32 CA192779/CA/NCI NIH HHS/United States

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