首页> BMJ open> Randomised placebo-controlled trial of combination ACE inhibitor and beta-blocker therapy to prevent cardiomyopathy in children with Duchenne muscular dystrophy? (DMD Heart Protection Study): a protocol study.

Randomised placebo-controlled trial of combination ACE inhibitor and beta-blocker therapy to prevent cardiomyopathy in children with Duchenne muscular dystrophy? (DMD Heart Protection Study): a protocol study.

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第一作者： John P,Bourke

第一单位： Department of Cardiology, Freeman Hospital, NUTH NHS Hospitals Foundation Trust, Newcastle upon Tyne, Tyne & Wear, UK.

作者： John P,Bourke ^[1] ; Gillian,Watson ^[2] ; Francesco,Muntoni ^[3] ; Stefan,Spinty ^[4] ; Helen,Roper ^[5] ; Michela,Guglieri ^[6] ; Chris,Speed ^[2] ; Elaine,McColl ^[2] ; Ashish,Chikermane ^[7] ; Sandeep,Jayawant ^[8] ; Satish,Adwani ^[9] ; Tracey,Willis ^[10] ; Jennifer,Wilkinson ^[2] ; Andrew,Bryant ^[11] ; Thomas,Chadwick ^[11] ; Ruth,Wood ^[2] ; Kate,Bushby ^[6] ; DMD Heart Protection study group

作者单位： Department of Cardiology, Freeman Hospital, NUTH NHS Hospitals Foundation Trust, Newcastle upon Tyne, Tyne & Wear, UK. ^[1] Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK. ^[2] Developmental Neuroscience, Dubowitz Neuromuscular Centre, London, UK.;Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. ^[3] Department of Paediatric Neurology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK. ^[4] Department of Paediatrics, Heart of England NHS Foundation Trust, Birmingham, UK. ^[5] John Walton Muscular Dystrophy Research Centre, Newcastle University, Newcastle upon Tyne, Tyne & Wear, UK. ^[6] Department of Cardiology, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK. ^[7] Department of Paediatric Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. ^[8] Department of Paediatric Cardiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. ^[9] Muscle Team, Robert Jones and Agnes Hunt Hospital, Oswestry, UK. ^[10] Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK. ^[11]

关键词 ace-inhibitor beta-blocker cardiac dystrophinopathy duchenne muscular dystrophy prophylactic therapy